PUBLICATIONS

(27) Mathes Hewage, A.; Nayebi Gavgani, H.; Chi, D.; Qiu, B.; Geiger, J. H.; Draths, K. Cg10062 Catalysis Forges a Link between Acetylenecarboxylic Acid and Bacterial Metabolism. Biochemistry 2021, 60 (51), 3879–3886.

(26) Gruenberg, M.; Irla, M.; Myllek, S.; Draths, K. Characterization of Two 3-Deoxy-D-Arabino-Heptulosonate 7-Phosphate Synthases from Bacillusmethanolicus. Protein Expr. Purif. 2021, 188, 105972.

(25) Ran, N.; Draths, K. M.; Frost, J. W. Creation of a Shikimate Pathway Variant. J. Am. Chem. Soc. 2004, 126 (22), 6856–6857. https://doi.org/10.1021/ja049730n.

(24) Yi, J.; Draths, K. M.; Li, K.; Frost, J. W. Altered Glucose Transport and Shikimate Pathway Product Yields in E. coli. Biotechnology Progress 2003, 19 (5), 1450–1459. https://doi.org/10.1021/bp0340584.

(23) Chandran, S. S.; Yi, J.; Draths, K. M.; Daeniken, R. von; Weber, W.; Frost, J. W. Phosphoenolpyruvate Availability and the Biosynthesis of Shikimic Acid. Biotechnology Progress 2003, 19 (3), 808–814. https://doi.org/10.1021/bp025769p.

(22) Yi, J.; Li, K.; Draths, K. M.; Frost, J. W. Modulation of Phosphoenolpyruvate Synthase Expression Increases Shikimate Pathway Product Yields in E. Coli. Biotechnology Progress 2002, 18 (6), 1141–1148. https://doi.org/10.1021/bp020101w.

(21) Niu, W.; Draths, K. M.; Frost, J. W. Benzene-Free Synthesis of Adipic Acid. Biotechnology Progress 2002, 18 (2), 201–211. https://doi.org/10.1021/bp010179x.

(20) Ran, N.; Knop, D. R.; Draths, K. M.; Frost, J. W. Benzene-Free Synthesis of Hydroquinone. J. Am. Chem. Soc. 2001, 123 (44), 10927–10934. https://doi.org/10.1021/ja016460p.

(19) Knop, D. R.; Draths, K. M.; Chandran, S. S.; Barker, J. L.; von Daeniken, R.; Weber, W.; Frost, J. W. Hydroaromatic Equilibration During Biosynthesis of Shikimic Acid. J. Am. Chem. Soc. 2001, 123 (42), 10173–10182. https://doi.org/10.1021/ja0109444.

(18) Gibson, J. M.; Thomas, P. S.; Thomas, J. D.; Barker, J. L.; Chandran, S. S.; Harrup, M. K.; Draths, K. M.; Frost, J. W. Benzene-Free Synthesis of Phenol. Angewandte Chemie International Edition 2001, 40 (10), 1945–1948. https://doi.org/10.1002/1521-3773(20010518)40:10<1945::AID-ANIE1945>3.0.CO;2-5.

 

(17) Kambourakis, S.; Draths, K. M.; Frost, J. W. Synthesis of Gallic Acid and Pyrogallol from Glucose:  Replacing Natural Product Isolation with Microbial Catalysis. J. Am. Chem. Soc. 2000, 122 (37), 9042–9043. https://doi.org/10.1021/ja000853r.

(16) Hansen, C. A.; Dean, A. B.; Draths, K. M.; Frost, J. W. Synthesis of 1,2,3,4-Tetrahydroxybenzene from d-Glucose:  Exploiting Myo-Inositol as a Precursor to Aromatic Chemicals. J. Am. Chem. Soc. 1999, 121 (15), 3799–3800. https://doi.org/10.1021/ja9840293.

(15) Draths, K. M.; Knop, D. R.; Frost, J. W. Shikimic Acid and Quinic Acid:  Replacing Isolation from Plant Sources with Recombinant Microbial Biocatalysis. J. Am. Chem. Soc. 1999, 121 (7), 1603–1604. https://doi.org/10.1021/ja9830243.

(14) Li, K.; Mikola, M. R.; Draths, K. M.; Worden, R. M.; Frost, J. W. Fed-Batch Fermentor Synthesis of 3-Dehydroshikimic Acid Using Recombinant Escherichia Coli. Biotechnology and Bioengineering 1999, 64 (1), 61–73. https://doi.org/10.1002/(SICI)1097-0290(19990705)64:1<61::AID-BIT7>3.0.CO;2-G.

(13) Snell, K. D.; Draths, K. M.; Frost, J. W. Synthetic Modification of the Escherichia Coli Chromosome:  Enhancing the Biocatalytic Conversion of Glucose into Aromatic Chemicals. J. Am. Chem. Soc. 1996, 118 (24), 5605–5614. https://doi.org/10.1021/ja9538041.

(12) Richman, J. E.; Chang, Y.-C.; Kambourakis, S.; Draths, K. M.; Almy, E.; Snell, K. D.; Strasburg, G. M.; Frost, J. W. Reaction of 3-Dehydroshikimic Acid with Molecular Oxygen and Hydrogen Peroxide:  Products, Mechanism, and Associated Antioxidant Activity. J. Am. Chem. Soc. 1996, 118 (46), 11587–11591. https://doi.org/10.1021/ja952317i.

(11) Frost, J. W.; Draths, K. M. Biocatalytic Syntheses of Aromatics From D-Glucose: Renewable Microbial Sources of Aromatic Compounds. Annu. Rev. Microbiol. 1995, 49 (1), 557–579. https://doi.org/10.1146/annurev.mi.49.100195.003013.

(10) Draths, K. M.; Frost, J. W. Environmentally Compatible Synthesis of Catechol from D-Glucose. J. Am. Chem. Soc. 1995, 117 (9), 2395–2400. https://doi.org/10.1021/ja00114a003.

(9) Frost, J.; Draths, K. Sweetening Chemical Manufacture. Chem. Br. 1995, 31 (3), 206–210.

(8) Draths, K. M.; Frost, J. W. Environmentally Compatible Synthesis of Adipic Acid from D-Glucose. J. Am. Chem. Soc. 1994, 116 (1), 399–400. https://doi.org/10.1021/ja00080a057.

(7) MacDonald, M. E.; Ambrose, C. M.; Duyao, M. P.; Myers, R. H.; Lin, C.; Srinidhi, L.; Barnes, G.; Taylor, S. A.; James, M.; Groot, N.; MacFarlane, H.; Jenkins, B.; Anderson, M. A.; Wexler, N. S.; Gusella, J. F.; Bates, G. P.; Baxendale, S.; Hummerich, H.; Kirby, S.; North, M.; Youngman, S.; Mott, R.; Zehetner, G.; Sedlacek, Z.; Poustka, A.; Frischauf, A.-M.; Lehrach, H.; Buckler, A. J.; Church, D.; Doucette-Stamm, L.; O’Donovan, M. C.; Riba-Ramirez, L.; Shah, M.; Stanton, V. P.; Strobel, S. A.; Draths, K. M.; Wales, J. L.; Dervan, P.; Housman, D. E.; Altherr, M.; Shiang, R.; Thompson, L.; Fielder, T.; Wasmuth, J. J.; Tagle, D.; Valdes, J.; Elmer, L.; Allard, M.; Castilla, L.; Swaroop, M.; Blanchard, K.; Collins, F. S.; Snell, R.; Holloway, T.; Gillespie, K.; Datson, N.; Shaw, D.; Harper, P. S. A Novel Gene Containing a Trinucleotide Repeat That Is Expanded and Unstable on Huntington’s Disease Chromosomes. Cell 1993, 72 (6), 971–983. https://doi.org/10.1016/0092-8674(93)90585-E.

(6) Draths, K. M.; Ward, T. L.; Frost, J. W. Biocatalysis and Nineteenth Century Organic Chemistry: Conversion of D-Glucose into Quinoid Organics. J. Am. Chem. Soc. 1992, 114 (24), 9725–9726. https://doi.org/10.1021/ja00050a099.

(5) Draths, K. M.; Pompliano, D. L.; Conley, D. L.; Frost, J. W.; Berry, A.; Disbrow, G. L.; Staversky, R. J.; Lievense, J. C. Biocatalytic Synthesis of Aromatics from D-Glucose: The Role of Transketolase. J. Am. Chem. Soc. 1992, 114 (10), 3956–3962. https://doi.org/10.1021/ja00036a050.

(4) Draths, K. M.; Frost, J. W. Conversion of D-Glucose into Catechol: The Not-so-Common Pathway of Aromatic Biosynthesis. J. Am. Chem. Soc. 1991, 113 (24), 9361–9363. https://doi.org/10.1021/ja00024a048.

(3) Avila, L. Z.; Draths, K. M.; Frost, J. W. Metabolites Associated with Organophosphonate C-P Bond Cleavage: Chemical Synthesis and Microbial Degradation of [32P]-Ethylphosphonic Acid. Bioorganic & Medicinal Chemistry Letters 1991, 1 (1), 51–54. https://doi.org/10.1016/S0960-894X(01)81089-1.

(2) Draths, K. M.; Frost, J. W. Genomic Direction of Synthesis during Plasmid-Based Biocatalysis. J. Am. Chem. Soc. 1990, 112 (26), 9630–9632. https://doi.org/10.1021/ja00182a028.

(1) Draths, K. M.; Frost, J. W. Synthesis Using Plasmid-Based Biocatalysis: Plasmid Assembly and 3-Deoxy-D-Arabino-Heptulosonate Production. J. Am. Chem. Soc. 1990, 112 (4), 1657–1659. https://doi.org/10.1021/ja00160a071.

Creation of a Shikimate Pathway Variant.
Benzene-Free Synthesis of Phenol.gif